Advancing personalised cancer treatment through patient “avatars”

The NORLUX Neuro-Oncology Laboratory at the LIH Department of Oncology (DONC), in collaboration with the Centre Hospitalier de Luxembourg (CHL), the Laboratoire National de Santé (LNS), the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and other international partners, established a large collection of patient-derived glioma organoids and xenograft models that mimic the specific features of patient brain tumours. These tools will allow the establishment of personalised drug efficacy studies, thus increasing the chances of success of clinical trials and improving clinical outcomes for patients. The findings were presented in a recent publication in the international peer-reviewed journal Acta Neuropathologica.

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Acta Neutopathologica (2020)

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology